|
KMID : 1137020170280050010
|
|
Journal of Gynecologic Oncology
2017 Volume.28 No. 5 p.10 ~ p.10
|
|
|
Prospective comparison of hybrid capture 2 and SPF10-LiPA for carcinogenic human papillomavirus detection and risk prediction of cervical cancer: a population-based cohort study in China
|
|
Dong Li
Feng Rui Mei
Zhang Li
Xu Xiao Qian
Zhao Xue Lian
Wang Margaret Zhuoer
Qiao You Lin
Zhao Fang Hui
|
|
|
Abstract
|
|
|
Objective: To investigate the extent of the cross-reactivity of hybrid capture 2 (HC2) assay and evaluate the potential effect of cross-reactivity on the long-term risk for cervical cancer and precancers.
Methods: Based on the Shanxi Province Cervical Cancer Screening Study-I (SPOCCS-I) cohort from 2005 to 2014 in Shanxi, China, SPF10-line probe assay (LiPA) was performed in all 598 HC2 positive and 300 random-selected HC2 negative cervical specimens. Ten-year cumulative incidence rate (CIR) of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) of these two tests was evaluated using Kaplan-Meier methods. Possible human papillomavirus (HPV) types to be cross-reacted by HC2 were also analyzed.
Results: The overall agreement between HC2 and SPF10-LiPA for detecting carcinogenic HPV was 73.27%. The highest 10-year cumulative risk of CIN2+ was observed in both HC2 positive and LiPA-carcinogenic HPV positive women (25.70%; 95% confidence interval [CI]=23.55%?27.91%), followed by HC2 positive but LiPA-non-carcinogenic HPV positive women (9.97%; 95% CI=8.57%?11.50%), HC2 negative but LiPA-carcinogenic HPV positive (2.56%; 95% CI=2.44%?2.70%) and HC2 positive but LiPA-HPV negative (1.85%; 95% CI=1.78%?1.92%) women. The proportion of cross-reactivity of HC2 with untargeted carcinogenic types was 8.9%, most of which were attributable to HPV26, 73, 82, 69, 71, 53, 11, 43, and 54.
Conclusion: The noticeable high risk of CIN2+ in women infected with cross-reacted non-carcinogenic HPV and low risk in those with miss-to-detective carcinogenic HPV supported an overall good clinical performance of HC2 for a general cervical cancer screening.
|
|
|
KEYWORD
|
|
|
Human papillomavirus, Cervical Intraepithelial Neoplasia, Cumulative Incidence, Cohort Study, Assay
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
    
|
|